Brief Resolved Unexplained Events (BRUE)

ALTE has been deprecated and replaced with BRUE. Apparent Life-Threatening Events scared parents and led physicians to unnecessary testing. The American Academy of Pediatrics has issued the following guideline.

BRUE
====

STEP 1: Meets DEFINITION of BRUE
- BRIEF: less than 1 minute episode  
- RESOLVED: back to baseline/normal  
- UNEXPLAINED: no other etiology (no URI, vomiting, etc) 
- EVENT:
     - cyanosis or pallor (not erythema)
     - absent, decreased or irregular breathing
     - marked change in tone 
     - altered level of responsiveness  
- in a normal child, less than 1 year old 

STEP 2: Stratify as LOW risk  
- more than 60 days old 
- full term (gestational age more than 32w)
- 1st event and not in clusters
- less than 1 minute
- no CPR by *trained medical provider* 
- no concerning features on H&P

STEP 3: Consider TREATMENT options for LOW risk
- SHOULD DO: educate care giver, shared medical decision making regarding can-do items, CPR training for parents
- CAN DO: pertussis testing, ekg, serial observation, pulse oximetry
- DONT HAVE TO DO: admit, viral PCR, glucose, HCO3, lactate, Hgb, CT head (unless judgement says differently), UA
- SHOULD NOT DO: WBC, CSF, Cx, BMP, urine organic acids, CXR, echo, EEG, GERD tests, H2 blockers, anti-epileptics, no home monitoring

HIGH risk patients consider 
- abuse
- cardiac arrhythmias (family history of sudden death)
- infection (URI Sx)
- others guided by context
  1. Tieder JS, Bonkowsky JL, Etzel RA, Franklin WH, Gremse DA, Herman B, Katz ES, Krilov LR, Merritt JL 2nd, Norlin C, Percelay J, Sapién RE, Shiffman RN, Smith MB; SUBCOMMITTEE ON APPARENT LIFE THREATENING EVENTS. Brief Resolved Unexplained Events (Formerly Apparent Life-Threatening Events) and Evaluation of Lower-Risk Infants: Executive Summary. Pediatrics. 2016 May;137(5). https://www.ncbi.nlm.nih.gov/pubmed/27244836
Brief Resolved Unexplained Events (BRUE)

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